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May 2022, Vol 8, No. 5, Pages 669-788

Original Investigation

Mediators of Racial Disparity in the Use of Prostate Magnetic Resonance Imaging Among Patients With Prostate Cancer

Abstract Full Text
JAMA Oncol. 2022;8(5):687-696. doi:10.1001/jamaoncol.2021.8116

This cohort study uses data from the Surveillance, Epidemiology, and End Results database to identify clinical, sociodemographic, and structural processes underlying racial disparity in the use of prostate magnetic resonance imaging among men with a new diagnosis of prostate cancer.

Efficacy of HD201 vs Referent Trastuzumab in Patients With ERBB2-Positive Breast Cancer Treated in the Neoadjuvant Setting: A Multicenter Phase 3 Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. 2022;8(5):698-705. doi:10.1001/jamaoncol.2021.8171

This randomized clinical trial compare the efficacy of HD201 with referent trastuzumab for treating patients with ERBB2-positive breast cancer.

Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2022;8(5):706-714. doi:10.1001/jamaoncol.2022.0122

This phase 3 randomized clinical trial examines whether induction chemotherapy with paclitaxel, cisplatin, and capecitabine improves survival vs cisplatin and fluorouracil prior to chemoradiotherapy for patients with stage IVA to IVB nasopharyngeal carcinoma.

Rates of Guideline-Concordant Surgery and Adjuvant Chemotherapy Among Patients With Early-Stage Lung Cancer in the US ALCHEMIST Study (Alliance A151216)

Abstract Full Text
has audio
JAMA Oncol. 2022;8(5):717-728. doi:10.1001/jamaoncol.2022.0039

This cohort study examines patterns of guideline-concordant treatment among patients enrolled in a US-wide screening protocol for adjuvant treatment trials for resected non-small cell lung cancer.

Risk of Colorectal Cancer Associated With Lifetime Excess Weight

Abstract Full Text
JAMA Oncol. 2022;8(5):730-737. doi:10.1001/jamaoncol.2022.0064

This case-control study examines the use of a measure estimating the association between cumulative lifetime exposure to excess weight and the risk for colorectal cancer.

Efficacy and Safety of TRC105 Plus Pazopanib vs Pazopanib Alone for Treatment of Patients With Advanced Angiosarcoma: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. 2022;8(5):740-747. doi:10.1001/jamaoncol.2021.3547

This randomized clinical trial investigates whether carotuximab plus pazopanib improves progression-free survival vs pazopanib alone in adult patients with advanced angiosarcoma.

Association of Patient-Reported Outcomes With Subsequent Nonfatal Self-injury After a New Cancer Diagnosis

Abstract Full Text
online only
JAMA Oncol. 2022;8(5):e220203. doi:10.1001/jamaoncol.2022.0203

This case-control study examines the associations between patient-reported outcome measures and subsequent nonfatal self-injury in patients with cancer.

Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients

Abstract Full Text
open access online only has active quiz
JAMA Oncol. 2022;8(5):e220446. doi:10.1001/jamaoncol.2022.0446

This comparative effectiveness study of immunocompromised patients and healthy controls in Switzerland examines differences in the magnitude and durability of neutralizing antibody responses against the original SARS-CoV-2 and several variants of concern according to the mRNA-1273 and BNT162b2 vaccines.

Brief Report

Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida

Abstract Full Text
open access has active quiz
JAMA Oncol. 2022;8(5):748-754. doi:10.1001/jamaoncol.2022.0001

This cohort study investigates the immune response of patients with cancer to the first and second doses of the COVID-19 mRNA-1273 vaccination.

Differences in Thickness-Specific Incidence and Factors Associated With Cutaneous Melanoma in the US From 2010 to 2018

Abstract Full Text
JAMA Oncol. 2022;8(5):755-759. doi:10.1001/jamaoncol.2022.0134

This population-based cohort study examines patterns in tumor thickness–specific incidence in patients with cutaneous melanoma.

Research Letter

Use of Early Intrathecal Therapy to Manage High-Grade Immune Effector Cell-Associated Neurotoxicity Syndrome

Abstract Full Text
JAMA Oncol. 2022;8(5):773-775. doi:10.1001/jamaoncol.2022.0070

This case series describes the use of early intrathecal steroid administration to manage high-grade and steroid-refractory immune effector cell-associated neurotoxicity syndrome among patients with B-cell non-Hodgkin lymphoma.

Self-reported Transportation Barriers to Health Care Among US Cancer Survivors

Abstract Full Text
JAMA Oncol. 2022;8(5):775-778. doi:10.1001/jamaoncol.2022.0143

This cross-sectional study uses data from the 2014-2018 National Health Interview Survey to examine various characteristics of US cancer survivors who experience delays in care due to transportation barriers.

Association of Changes in Medicaid Dental Benefits With Localized Diagnosis of Oral Cavity Cancer

Abstract Full Text
JAMA Oncol. 2022;8(5):778-780. doi:10.1001/jamaoncol.2022.0149

This cohort study uses data from the Surveillance, Epidemiology, and End Results database to examine the association between changes in Medicaid dental insurance coverage in California between 2009 and 2014 and rates of localized oral cavity cancer diagnoses.

Review

Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review

Abstract Full Text
has active quiz
JAMA Oncol. 2022;8(5):760-769. doi:10.1001/jamaoncol.2021.8196

This review explores the characteristics of ERBB2-positive metastatic colorectal cancer and the potential of treatment with anti-ERBB2 agents.

JAMA Oncology Clinical Challenge

An Intramedullary Enigma

Abstract Full Text
has active quiz
JAMA Oncol. 2022;8(5):770-771. doi:10.1001/jamaoncol.2022.0462

A woman in her 60s was diagnosed with high-grade leiomyosarcoma of the uterus, which had been treated with hysterectomy and bilateral salpingo-oophorectomy, and subsequently had relapsed in the liver and spine. What is your diagnosis?

Viewpoint

Oncological Applications of Deep Learning Generative Adversarial Networks

Abstract Full Text
JAMA Oncol. 2022;8(5):677-678. doi:10.1001/jamaoncol.2021.8202

This Viewpoint assesses the use of generative adversarial networks to overcome current challenges and further revolutionize the use of deep learning in oncology.

Biased Evaluation in Cancer Drug Trials—How Use of Progression-Free Survival as the Primary End Point Can Mislead

Abstract Full Text
JAMA Oncol. 2022;8(5):679-680. doi:10.1001/jamaoncol.2021.8206

This Viewpoint discusses whether the use of progression-free survival as the primary end point in cancer drug trials can result in misleading interpretations of improved overall survival and quality of life.

Palliative Care Is the Umbrella, Not the Rain—A Metaphor to Guide Conversations in Advanced Cancer

Abstract Full Text
JAMA Oncol. 2022;8(5):681-682. doi:10.1001/jamaoncol.2021.8210

This Viewpoint provides a metaphor for physicians to use as a communication tool to explain the benefits of early palliative care to patients with advanced cancer.

Editorial

JAMA Oncology—The Year in Review, 2021

Abstract Full Text
free access
JAMA Oncol. 2022;8(5):685-686. doi:10.1001/jamaoncol.2022.0262
Invited Commentary

Racist Factors Underlying Prostate Cancer Disparities

Abstract Full Text
JAMA Oncol. 2022;8(5):696-697. doi:10.1001/jamaoncol.2021.7271

Induction Chemotherapy for Advanced Nasopharyngeal Carcinoma—Is This the New Standard of Care?

Abstract Full Text
JAMA Oncol. 2022;8(5):715-716. doi:10.1001/jamaoncol.2022.0082

Translating Clinical Trial Evidence to Routine Practice—How Do We Overcome the Barriers?

Abstract Full Text
JAMA Oncol. 2022;8(5):728-729. doi:10.1001/jamaoncol.2022.0038

Exposure Histories and Cancer Risk—What Can We Learn?

Abstract Full Text
JAMA Oncol. 2022;8(5):738-739. doi:10.1001/jamaoncol.2022.0061
JAMA Oncology Patient Page

Financial Toxicity of Cancer Treatment

Abstract Full Text
free access
JAMA Oncol. 2022;8(5):788. doi:10.1001/jamaoncol.2021.7987

This JAMA Oncology Patient Page explains what financial toxicity is and offers treatment approaches.

Cancer Care Chronicles

A Radiation Oncologist’s Experience With Medical Aid in Dying

Abstract Full Text
JAMA Oncol. 2022;8(5):683-684. doi:10.1001/jamaoncol.2022.0076

This essay discusses medical aid in dying (MAID) and encourages physicians to inquire about medical societies’ stances on MAID and to consider a position of engaged neutrality.

Poetry and Oncology

How to Breathe

Abstract Full Text
JAMA Oncol. 2022;8(5):786. doi:10.1001/jamaoncol.2021.8215
Comment & Response

Internal Mammary Nodal Irradiation Debate for Node-Positive Breast Cancer—Has the Needle Moved?

Abstract Full Text
JAMA Oncol. 2022;8(5):780. doi:10.1001/jamaoncol.2022.0226

Internal Mammary Nodal Irradiation Debate for Node-Positive Breast Cancer—Has the Needle Moved?—Reply

Abstract Full Text
JAMA Oncol. 2022;8(5):780-781. doi:10.1001/jamaoncol.2022.0229

Do We Have Enough Evidence to Propose a Preferred Total Neoadjuvant Therapy Sequence for Patients With Locally Advanced Rectal Cancer?

Abstract Full Text
JAMA Oncol. 2022;8(5):781-782. doi:10.1001/jamaoncol.2022.0232

Do We Have Enough Evidence to Propose a Preferred Total Neoadjuvant Therapy Sequence for Patients With Locally Advanced Rectal Cancer?—Reply

Abstract Full Text
JAMA Oncol. 2022;8(5):782-783. doi:10.1001/jamaoncol.2022.0235

Cabozantinib for Treatment of Brain Metastases in Patients With Renal Cell Carcinoma

Abstract Full Text
JAMA Oncol. 2022;8(5):783. doi:10.1001/jamaoncol.2022.0052

Cabozantinib for Treatment of Brain Metastases in Patients With Renal Cell Carcinoma

Abstract Full Text
JAMA Oncol. 2022;8(5):783-784. doi:10.1001/jamaoncol.2022.0049
Correction

Error in Author Surname

Abstract Full Text
free access
JAMA Oncol. 2022;8(5):784. doi:10.1001/jamaoncol.2022.0909
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2022;8(5):669. doi:10.1001/jamaoncol.2021.5496
Peer Reviewers List

JAMA Oncology Peer Reviewers in 2021

Abstract Full Text
free access online only
JAMA Oncol. 2022;8(5):e220185. doi:10.1001/jamaoncol.2022.0185
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